Regulation of G protein subunit composition in cardiomyocytes: pharmacological implications
نویسندگان
چکیده
منابع مشابه
RGS4 inhibits G-protein signaling in cardiomyocytes.
BACKGROUND RGS family members are GTPase-activating proteins for heterotrimeric Gq and Gi proteins. RGS genes are expressed in heart tissue and in cultured cardiomyocytes. There is evidence that altered RGS gene expression may contribute to the pathogenesis of cardiac hypertrophy and failure. METHODS AND RESULTS We investigated the ability of RGS proteins to block G-protein signaling in vivo ...
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Several regulators of G protein signaling (RGS) proteins contain a G protein g-subunit-like (GGL) domain, which, as we have shown, binds to Gb5 subunits. Here, we extend our original findings by describing another GGLdomain-containing RGS, human RGS6. When RGS6 is coexpressed with different Gb subunits, only RGS6 and Gb5 interact. The expression of mRNA for RGS6 and Gb5 in human tissues overlap...
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ژورنال
عنوان ژورنال: Naunyn-Schmiedeberg's Archives of Pharmacology
سال: 2013
ISSN: 0028-1298,1432-1912
DOI: 10.1007/s00210-013-0864-1